The “scenario” in the book is that of a “biological weapons lab accident,” where a scientist working to modify pneumonic plague into a deadly biological weapon experiences remorse and tries to destroy it. But the small fire he lights causes an explosion that propels the Yersinia pestis bacteria (which causes the plague) into the atmosphere. In the process, he becomes infected with his weaponized pneumonic plague, although he doesn’t yet know it.
Although most of us cannot directly influence negotiations about strengthening the BWC, there are things that we can do to support such efforts and to lessen the increasingly grave dangers that confront us.
The next morning, he goes to an Orthodox church to confess where, by coughing in the midst of confession, he infects the priest, as well as the next person in line—a pre-med foreign exchange student, who is back in this small Russian town visiting family—before returning to the US shortly thereafter, where he is studying and doing volunteer work with homeless people. The student subsequently infects scores on Skid Row, who, in turn, infect the first responders who come to help them and, ultimately, the whole city of Los Angeles.
Following his confession, the scientist goes into the woods to shoot himself but collapses from the symptoms of plague. He is found by men on an international hunting trip, who administer mouth-to-mouth resuscitation and carry him back to their hunting lodge, where he is collected by officials. After dining together, using the same sauna and steam bath, and driving to the airport in the same van, seven of the hunters board flights to six of the world’s seven continents, while another goes off on a sea cruise—spreading pneumonic plague on their flights and sea voyage—and ultimately around the world.
In the real-world scenario, reported on October 2, Darya Shipilova, a 28-year old laboratory technician working in an “Anti-Plague Institute” in Irkutsk, Siberia died, according to Russian officials, of “a pneumonia of unknown etiology.” A Russian news agency reported that she had broken a test tube containing live bacteria of the pneumonic plague pathogen, leading to widespread speculation that she had, indeed, died of pneumonic plague.
These concerns were reinforced by reports that Russian health authorities imposed sweeping quarantine restrictions on the lab where she worked, the hospital where she died, and other nearby hospitals. Neighbors also reported that workers in protective suits and gas masks repeatedly disinfected the building where she lived, telling residents that it was “for cockroaches,” although the building has no cockroaches. More recently, Russia’s health agency asserted that the plague was not detected in follow-up tests of “thousands of people in the region.”
The overall opacity (a familiar playbook for crises in Russia) of Russian public health officials in responding to urgent requests for more information from the World Health Organization, the US, and other governments led to considerable disquiet around the world.
When asked if her death was related to a bioweapon, President Donald Trump responded, not very reassuringly, “We don’t think so.” He also acknowledged the similarities in how Chinese officials handled Covid-19 before it became a global pandemic: “China didn’t say much, and Russia is not saying much either.”
The Biological Weapons Convention Was Supposed to Prevent This, Then Came the Secret Soviet Biological Weapons Program
The 1925 Geneva Protocol banned the use of biological weapons, but not their development or possession. Although ratified by a number of countries in the 1920s and 30s, it wasn’t ratified by the US until 1975.
After 27 years of a US biological weapons program, President Richard Nixon unexpectedly announced on November 25, 1969 that the US would unilaterally end its offensive biological weapons program, stating, “The United States shall renounce the use of lethal biological agents and weapons, and all other methods of biological warfare… [and] confine its biological research to defensive measures such as immunization and safety measures.” Over the next years, US biological weapons stocks were destroyed with the process completed in May 1972.
Subsequently, the United Nations Conference on Disarmament negotiated “The Biological Weapons Convention” (BWC), the first multilateral treaty to ban an entire class of weapons of mass destruction. It was opened for signature on April 10, 1972 and signed by the US, Great Britain, and the Soviet Union the same day. It entered into force on March 26, 1975. Currently, it has 189 State Parties and four Signatory States, with only four States outside the Convention.
Because it was the first of its kind, however, the BWC lacked the important monitoring and verification procedures that were later included in the Chemical Weapons Convention. There are no mandatory verified declarations of biological facilities or activities; no inspections or site visits to verify compliance; no international organization to oversee implementation; and no penalties for non-compliance, although complaints can be made to the UN Security Council (which are subject to veto by any of the five Permanent Members). Only four staff are involved in its tiny Implementation Support Unit, compared with over 500 for the Chemical Weapons Convention.
In spite of the Soviet Union becoming a signatory to the BWC in 1972, the USSR continued to covertly develop and produce offensive biological weapons in what became the world’s largest and most sophisticated biological weapons program, with 40-50 biological research facilities scattered around the country, employing 65,000 people. The aim was to create “exotic biological weapons using techniques made possible by recombinant DNA.” Recombinant DNA, also called genetic engineering, involves joining the DNA from two entirely different species to make new pathogens.
Not detecting this vast biological weapons program was one of the biggest intelligence failures of the Cold War as it was totally unknown in the West until 1989, when a Soviet scientist, Vladimir Pasechnik, defected, shocking the British Intelligence Services and the CIA with details of the massive program and its deadly stockpiles. They learned that the Soviets had “genetically engineered a strain of Yersinia pestis to resist antibiotics” and had also stockpiled vast volumes of other deadly pathogens in the labs’ freezers, such as smallpox, anthrax, ebola, Marburg virus disease, and many others—all weaponized to kill populations in the most diabolical manner.
The terrifying extent of this biowarfare program was later confirmed by other defecting Soviet scientists, especially after the collapse of the Soviet Union in 1991. In January 1992, Boris Yeltsin admitted that he knew about the program and pledged to close down the institutes, retire their directors, and ask for international inspections. But the two generals he appointed to carry out this mission resisted his orders. In 1992, a Trilateral Agreement was signed by Russia with the United States and the United Kingdom “promising to end biological weapons programs and convert facilities to benevolent purposes, but compliance with the agreement—and the fate of the former Soviet bio-agents and facilities—is still mostly undocumented.”
The State Department’s 2025 compliance report states: “The United States assesses that Russia maintains an offensive biological warfare program and is in violation of its obligations under Article I and II of the BWC… Key military biological facilities associated with the Soviet offensive program remain, inaccessible and not transparent, nearly 30 years after Yeltsin’s decree.”
Jacobsen’s Book Is Based on the Secret Soviet Biological Weapons Program
The latter part of Jacobsen’s book deals with the breakdown of law and order, as mass death and panic take hold and cause chaos. Ultimately, the president deploys the Insurrection Act, whereby military forces attempt to establish martial law for the first time in American history. Just as they are about to release the strategic national stockpiles of medicine, scientists at the US Army Medical Research Institute of Infectious Disease receive their first bacterial specimens (from the infected hunter who landed in Dallas and died in a local hospital). Microbiologists in biocontainment suits examine the specimens, and plague cultures are grown and used to test for antibiotic resistance in small animals. Simultaneously, microbiologists extract DNA from the specimen and feed it into a high-speed sequencing machine to get a genetic fingerprint of the pathogen.
What they discover is appalling—the organism has been bioengineered and “looks alarmingly like a 21st century version of something Russian scientists worked on during the Soviet-era secret biological weapons programs.” It is a combination of two pathogens, one concealed within another, referred to as a “bobby-trap bio-weapon,” whereby, after a person becomes infected with pneumonic plague and takes antibiotics as soon as possible under the assumption they will be cured, the antibiotics trigger the chimera weapon’s bobby-trap mechanism—in this fictional case, the Venezuelan equine encephalitis gene which has been covertly spliced into the Yersinia pestis genome to cause acute neurological symptoms and death. As a result, there is no cure.
As Annie Jacobsen declares:
The book is not meant to create unnecessary fear. It is meant to make clear what is now possible, and what is at stake. The tools to engineer life are advancing faster than the rules that govern them. This gap is where existential danger lives. The point is not panic; the point is pressure. To demand guardrails, oversight, and accountability before the science outruns our ability to control it. Before we set something irreversible in motion.
Although the real-life situation in Siberia will hopefully not turn out to be the same as in Annie Jacobsen’s book, it should cause us to take notice.
Attempts to Improve the Biological Weapons Convention
Serious attempts have been made in the past to strengthen the BWC but without success. An Ad Hoc Group labored from 1995 to 2001 to create a protocol where states would submit declarations of treaty-relevant facilities and activities to an international body that would conduct routine on-site visits, as well as challenge inspections of suspect facilities and activities. But the draft was rejected by the US under President George W. Bush, who argued that it could harm US national security. Nothing more happened for many years.
Another attempt is currently underway, although progress is slow. A Biological and Toxin Weapons Convention Working Group was established at the 2022 BWC Review Conference and has been working steadily over the last four years to come up with the text of draft recommendations before the 2027 BWC Review Conference. At their August meeting this year, 90.6% of the text had been agreed, although fundamental disagreements over verification frameworks, transfer controls, and funding remain—and tensions are high.
The chair of the Working Group has highlighted the urgency, arguing that the sudden convergence of artificial intelligence and biology is “creating new security challenges,” warning that a gap “may emerge between these rapidly advancing capabilities and our collective ability to understand their governance and prevent their misuse.”
What We Can Do
Although most of us cannot directly influence negotiations about strengthening the BWC, there are things that we can do to support such efforts and to lessen the increasingly grave dangers that confront us.
We can be sure to vote in the upcoming midterms for Democratic candidates, who have been more likely to support regulatory controls in Congress, as well as multilaterally. We can support these candidates with financial contributions and by working on their campaigns to ensure that they get elected, since time is short. Once elected, we can strive to persuade them to urgently implement appropriate policies.
After all, who wants human extinction? Presumably, none of us—no matter how jaded we may have become.
We can educate ourselves about the threats by reading widely, including Jacobsen’s excellent books, as well as opinion pieces on the subject, such as ones I’ve written on AI and nuclear weapons. We can do online research to identify, join, financially support, and work with others in public advocacy organizations against threats that are of particular concern to us. We can attend protest rallies and discuss our concerns with friends, encouraging them to also become active, so that we can develop a large public constituency to combat these extreme dangers.
Just a couple of days ago, on October 11, The Lancet Commission on 21st Century Global Threats to Health highlighted 17 major threats to human health over the next 75 years, asserting that, “Malicious use of AI, including bioweapons, and nuclear conflict with nuclear famine [caused by nuclear winter] carry risks of extinction in the next 75 years.” There are so many existential dangers to confront that it can sometimes feel overwhelming and lead us to a state of helplessness when what we need, instead, is a pro-active approach that will foster resourcefulness.
By facing up to our natural tendency to avoid frightening information and by confronting our fears head-on, we can gain a true sense of self-efficacy and social responsibility. In this way, we can save those we love; ensure that future generations thrive; preserve the rich cultural heritage we have created; protect the magnificent array of other species on Earth; and safeguard our beautiful, one-of-a-kind planet—from all of these truly insane and, frankly, evil machinations—often designed by normal people, who have been seduced by competitive processes; rationales that “everyone is doing it”; lucrative remuneration; lapse of conscience; and bad ideas into creating conditions for the most dystopian futures imaginable.
As Gareth Evans, former Australian foreign minister, former president and CEO of the International Crisis Group, and co-chair of the Commission on Nuclear Proliferation and Disarmament has recently commented with regard to the nuclear threat, “It is up to those of us who passionately believe in both the possibility and necessity of a nuclear weapon free world, however disappointed and frustrated we may be right now, to get out there and continue to campaign our hearts out for it.” I suggest that we extend his call to action to all the existential threats we face. After all, who wants human extinction? Presumably, none of us—no matter how jaded we may have become. We must assume responsibility for the continuation of our kind and choose human survival.
